Those receiving treatment often wonder How Acupuncture Works, because, after all, much about holistic pain relief is unknown outside of those practicing Traditional Chinese Medicine (TCM). While acupuncture has its origins in TCM, the practice has been extensively studied through the lens of modern science. Western medicine has sought to uncover the physiological mechanisms that explain how this ancient therapy alleviates pain, promotes healing, and restores balance to the body. By bridging Eastern philosophies with contemporary research, we gain valuable insights into acupuncture’s efficacy, providing a scientific foundation for its role in integrative healthcare.
Acupuncture works by stimulating the body’s intricate network of nerves, muscles, and connective tissues, triggering biological responses that can reduce inflammation, regulate the nervous system, and enhance overall well-being. Research highlights specific mechanisms, such as the release of neuromodulators like beta-endorphins, improved blood circulation at treatment sites, and the activation of brain regions involved in pain regulation. These findings help explain why acupuncture is effective for managing chronic pain, stress, and a wide array of other health concerns. Acupuncturist Dr Rachel Abare, OMD, offers the most effective holistic pain relief treatments in Reno, Nevada. Call to schedule a consultation, and restore a more enjoyable life today.
This post explores how acupuncture works from a Western medicine perspective, offering a comprehensive view of the biological processes that make this therapy a powerful tool for healing.

The Western Medicine Perspective on Acupuncture: A Detailed Exploration
Acupuncture, a practice with roots in Traditional Chinese Medicine, is increasingly understood through the lens of Western medical science. Modern research sheds light on how acupuncture achieves its effects, particularly in pain management and overall health restoration. This understanding revolves around several key mechanisms:
1. Extra-Segmental Analgesia
Acupuncture increases pain thresholds by triggering the release of neuromodulators, such as beta-endorphins. These substances act as the body’s natural painkillers:
- Neuromodulator Activity: Beta-endorphins bind to opioid receptors in the brain and spinal cord, suppressing pain signals and inducing a sense of well-being.
- Hormonal Regulation: Acupuncture’s effect on beta-endorphin release helps regulate stress responses, reducing inflammation and pain associated with chronic conditions.
- Clinical Applications: This mechanism is particularly beneficial for conditions like fibromyalgia, arthritis, and neuropathic pain, where the body’s ability to modulate pain is impaired.
2. Central Regulation
Acupuncture stimulates the limbic system and other deeper regions of the brain involved in pain processing, mood regulation, and stress response.
- Limbic System Activation: The limbic system, which includes the hypothalamus, hippocampus, and amygdala, plays a critical role in emotional processing and stress regulation. Acupuncture has been shown to normalize activity in these regions, reducing chronic stress and anxiety.
- Neurochemical Effects: It increases the release of serotonin and dopamine, neurotransmitters that elevate mood and contribute to pain relief.
- Pain Modulation: Acupuncture helps “retrain” the brain’s pain pathways, especially for conditions like migraines, chronic back pain, and post-traumatic stress disorder (PTSD).
3. Local Effects
At the needle insertion site, acupuncture works to induce significant physiological changes, primarily through the release of the neuropeptide CGRP (Calcitonin Gene-Related Peptide).
- CGRP Release: CGRP causes vasodilation, increasing blood flow and nutrient delivery to the local tissues. This promotes healing and reduces inflammation.
- Immune Response: Acupuncture can stimulate localized immune cells, releasing anti-inflammatory cytokines that accelerate tissue repair.
- Tissue Healing: Improved microcirculation reduces edema, facilitates the removal of waste products, and speeds up recovery from injuries or surgeries.
4. Segmental Analgesia
Acupuncture works to affect spinal segment activity, specifically the dorsal horn of the spinal cord, where pain signals are processed.
- Alpha-Delta Fiber Stimulation: By stimulating these sensory nerve fibers, acupuncture inhibits nociceptive signals (pain signals) traveling to the brain.
- Gate Control Theory: This mechanism aligns with the gate control theory of pain, which suggests that non-painful input (e.g., acupuncture) “closes the gate” to painful input, preventing the sensation of pain.
- Applications: This process is effective for neuropathic pain, sciatica, and pain radiating from specific spinal segments.
5. Myofascial Trigger-Point Release
Acupuncture effectively targets trigger points, which are hyper-irritable nodules in the muscle or connective tissue associated with pain and muscle tightness.
- Mechanical Disruption: Needle insertion into a trigger point physically disrupts muscle fibers, relieving tension and restoring normal muscle function.
- Neuromuscular Effects: This stimulation induces the release of acetylcholine, reducing excessive muscle contraction and improving range of motion.
- Vasodilation: Increased blood flow at the trigger point accelerates the removal of metabolic byproducts, reducing soreness and inflammation.
- Clinical Relevance: Trigger-point acupuncture is widely used for conditions like tension headaches, frozen shoulder, and chronic myofascial pain.

Why Acupuncture Works: Integration of Mechanisms
These mechanisms do not act in isolation; rather, they work synergistically. For example:
- Increased blood flow (local effects) enhances the transport of beta-endorphins (extra-segmental analgesia) to the affected area.
- Limbic system regulation (central regulation) reinforces the body’s natural pain-relief processes, complementing the immediate effects of segmental analgesia.
Broader Implications for Health
Chronic Pain: Acupuncture works by offering a non-pharmacological alternative for managing pain without the side effects of medications like opioids.
Stress and Mental Health: By balancing the nervous system, acupuncture promotes relaxation and mental clarity, aiding those with anxiety and depression.
Injury Recovery: Enhanced circulation and localized immune activation speed up healing after injuries or surgeries.
This comprehensive understanding of how acupuncture works through the scientific lens Western medicine validates its effectiveness, offering patients a blend of traditional wisdom and modern scientific insight.